Kleinelevin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Kleine levin syndrome archives hypersomnia foundation. Kleine levin syndrome genetic and rare diseases information. Kleine levin syndrome is rare, affecting an estimated 15 per million individuals.
The kleinelevin syndrome kls is a rare disorder of periodic hypersomnia and associated symptoms. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and. Kleinelevin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleinelevin syndrome are male. Imaging diagnostics refers to brain mri kleinelevin syndrome and other inherited sleep disorders inclusion criteria 29583 recurrent hypersomnia. Kleinelevin syndrome more details kls is a rare disease characterized by recurrent episodes of hypersomnia and to various degrees, behavioral or cognitive disturbances, compulsive eating behavior, and hypersexuality. Aug 02, 20 one of these is called kleine levin syndrome. Kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Kleinelevin syndrome kls alias sleeping beauty syndrome, is a rare sleep disorder. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition. More than 70% of all people who have kleine levin syndrome are males, and most of them tend to be adolescents when this is first diagnosed.
Autoimmunity has recently been proposed as a factor contributing to its pathogenesis. Kleinelevin syndrome is rare sleep disorder characterized by episodic hypersomnia, cognitive dysfunction, psychiatric and behavioral disturbances. Kleinelevin syndrome kls is a rare, relapsingremitting disease that affects mostly adolescents. Symptoms occur as episodes, typically lasting a few days to a few weeks. If patients do experience psychotic symptoms such as delusions or hallucinations, they are shortlived and parallel the duration of the. Kleinelevin syndrome sufferers feel a consistent urge to sleep. The disorder strikes adolescents primarily but can occur in younger children and adults. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. Many patients also experience hyperphagia, hypersexuality and other symptoms. It is rare for patients over the age of 30 years to present with their first.
It is characterized by episodes lasting from 1 to several weeks, and comprises neurological hypersomnia, confusion, slowness, amnesia and neuropsychiatric symptoms derealization and apathy. Connor has had kls since he was 11, he is in this recording. Participate in the kls research program blood samples from a new kls patients are tremendously. The kleine levin syndromeeffects of treatment with. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. Kleinelevin syndrome is rare, affecting an estimated 15 per million individuals.
Welcome to kls support uk we are a small charity offering help and support to those affected by kleinelevin syndrome also known as kleine levin syndrome or kls. An unusual occurrence of kleinelevin syndrome in a man. Nature and science of sleep dovepress kls foundation. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic.
Very recently, the hypersomnia foundation became aware of an opportunity to help shape the future of sleep research. Symptoms may last for days to weeks, include excessive food intake, lack of energy, disorientation, irritability, and sensitivity to noise. Inside edition, 2006, about kls in the us watch about kleine levin here imagine being so exhausted, so overwhelmed, that you could sleep almost non stop for weeks, or even maybe months. This site is like a library, you could find million book here by using search box in the. Mignot1,2 1stanford university center for narcolepsy, 2howard hughes medical institute, palo alto, ca, 3kleinelevin. Within the next decade max levin made the association between morbid hunger and periodic hypersomnolence and in 1962 critchley introduced. Kls is a rare disorder characterised by recurrent bouts of excessive sleep associated with reduced understanding of. The rarity of the syndrome, in combination with the clinical. May 16, 2016 in hypersomnias, idiopathic hypersomnia, kleine levin syndrome, narcolepsy, news, raising awareness, research, take action. Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Most patients with kleinelevin syndrome are adolescent males. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment.
Kleinelevin syndrome kls is rare, but is still the most common form of recurrent hypersomnia with a prevalence of 12 per million. Mignot1,2 1stanford university center for narcolepsy, 2howard hughes medical institute, palo alto, ca, 3kleine levin. Kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Treatments for kleinelevin syndrome stanford health care. Jul 10, 2017 kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Kleine levin syndrome etiopathogenesis and treatment.
Kleinelevin syndrome, hypersomnia, adolescent sleep disorder, hypersexuality. A rare condition that is characterized by periods of excessive drowsiness and sleep, lasting up to 20 hours per day. Kleinelevin syndrome is an extremely rare neurological entity characterized by recurrent episodes of hypersomnia which are sometimes associated with compulsive hyperphagia and behavioral changes. Check the full list of possible causes and conditions now.
Poppe m, friebel d, reuner u, todt h, koch r, heubner g. The full text of this article is available in pdf format. May 16, 2016 in hypersomnias, idiopathic hypersomnia, kleinelevin syndrome, narcolepsy, news, raising awareness, research, take action. The diagnosis is based on clinical criteria according to the american academy of sleep medicine classification 2005, including the cardinal symptom of periodic hypersomnia and behavioral and cognitive disturbances. Immune thrombocytopenic purpura is a relatively common autoimmune disease showing a lot of complexity. Kleine levin syndrome kls alias sleeping beauty syndrome, is a rare sleep disorder. Steve chapman an adult with kleine levin syndrome recorded on our local news channel. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. Spect in the kleinelevin syndrome, a possible diagnostic.
In a large cohort of 108 patients diagnosed with kleine levin syndrome, 25% had a complicated birth history and 15% had some degree of developmental delay. Kleine levin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Imaging diagnostics refers to brain mri kleine levin syndrome and other inherited sleep disorders inclusion criteria 29583 recurrent hypersomnia. Affected individuals may sleep for up to 20 hours per day during an episode. Hipotesis inmunogenetica find, read and cite all the research you need on researchgate. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting. Kleinelevin syndrome information page national institute. The disease predominantly affects adolescent males. Although no populationbased studies reporting on kls prevalence are available, it is generally considered an.
Kleine levin syndrome kleine levin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. In some cases, this means up to 20 hours a day are spent sleeping. Act today and let your voice be heard very recently, the hypersomnia foundation became aware of an opportunity to help shape the future of sleep research. Kleinelevin syndrome kleinelevin syndrome treatment. Kls support uk helping families affected by kleinelevin.
Recurrent episodes of excessive daytime sleepiness lasting for 2 days4 weeks episodes recur at least once per year alertness, cognitive function and behavior are normal between episodes hypersomnia and at least 1. Neuropsychological sequelae in kleinelevin syndrome. Kleinelevin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior. Kleine levin syndrome kls foundation, san jose, california. Mar 27, 2019 kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Affected individuals usually have excessive food intake and may be confused, irritable, and lethargic. Some aspects of the disease can be managed with medication, such as stimulants to combat the eds, but this is most effective only once the episodes have already decreased in severity. These serious episodes alternate with periods without any symptoms. It is characterized by recurring but reversible periods of excessive sleep up to 20 hours per day.
Beim kleinelevinsyndrom schlafen betroffene bis zu sechs monate am stuck. Request pdf kleinelevin syndrome kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. There is no specific, definitive treatment to cure or control kls. Some patients have hallucinations or sexual disinhibition. All books are in clear copy here, and all files are secure so dont worry about it. Connors story erin, connors mum talks on a boston radio station about what it is like to have a son with kleine levin syndrome and help they manage. Kleinelevin syndrome kls is a rare neurological disorder of unknown origin characterised by relapsingremitting episodes of hypersomnia in association with. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Kleine levin syndrome is a rare selflimited disorder which usually affects adolescent males and is characterized by episodic hypersomnia, increased appetite, and behavioralpsychiatric disturbances.
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